Title : Involvement of oxidative stress-induced ERK/JNK activation in the Cu(2+)/pyrrolidine dithiocarbamate complex-triggered mitochondria-regulated apoptosis in pancreatic β-cells.

Pub. Date : 2012 Feb 5

PMID : 22085843






1 Functional Relationships(s)
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1 Transfection with ERK2- and JNK-specific si-RNA and specific inhibitors SP600125 and PD98059 could inhibit ERK1/2 and JNK activation and attenuate MMP loss and caspase-3 activity induced by the Cu(2+)/PDTC complex. pyrazolanthrone mitogen activated protein kinase 3 Rattus norvegicus