Pub. Date : 2011 Dec 13
PMID : 22082678
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | BACKGROUND: The nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and the leukocyte-derived hemoprotein myeloperoxidase (MPO) are associated with cardiovascular diseases. | Nitric Oxide | myeloperoxidase | Homo sapiens |
2 | Activation of monocytes and polymorphonuclear neutrophils (PMNs) with concomitant release of MPO is regulated in a nitric oxide-dependent fashion. | Nitric Oxide | myeloperoxidase | Homo sapiens |
3 | CONCLUSIONS: ADMA profoundly impairs nitric oxide synthesis of PMNs, resulting in increased PMN adhesion to endothelial cells, superoxide generation, and release of MPO. | Nitric Oxide | myeloperoxidase | Homo sapiens |