Title : Vascular endothelial growth factor receptor 2 inhibition in-vivo affects tumor vasculature in a tumor type-dependent way and downregulates vascular endothelial growth factor receptor 2 protein without a prominent role for miR-296.

Pub. Date : 2012 Feb

PMID : 22075979






2 Functional Relationships(s)
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Protein Name
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1 Strikingly, vandetanib reduced protein expression of VEGFR2 in both models, whereas mRNA remained unaffected. vandetanib kinase insert domain receptor Homo sapiens
2 Our data demonstrate that VEGFR2/EGFR inhibition through vandetanib slows down both LLC and B16.F10 tumor growth. vandetanib kinase insert domain receptor Homo sapiens