Title : Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.

Pub. Date : 2012 Jan 2

PMID : 22074768






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The N93D/L109F TK2 mutant has lower activity for the endogenous nucleosides thymidine and deoxycytidine than wild type TK2, and its ectopic expression in therapeutic cells is not expected to alter nucleotide metabolism. Deoxycytidine thymidine kinase 2 Homo sapiens
2 The N93D/L109F TK2 mutant has lower activity for the endogenous nucleosides thymidine and deoxycytidine than wild type TK2, and its ectopic expression in therapeutic cells is not expected to alter nucleotide metabolism. Deoxycytidine thymidine kinase 2 Homo sapiens