Pub. Date : 2011 Nov 9
PMID : 22072694
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Overexpression of CREB in the nucleus accumbens shell increases cocaine reinforcement in self-administering rats. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | Chronic exposure to addictive drugs enhances cAMP response element binding protein (CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | Chronic exposure to addictive drugs enhances cAMP response element binding protein (CREB)-regulated gene expression in nucleus accumbens (NAc), and these effects are thought to reduce the positive hedonic effects of passive cocaine administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | Here, we used viral-mediated gene transfer to produce short- and long-term regulation of CREB activity in NAc shell of rats engaging in volitional cocaine self-administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 5 | Increasing CREB expression in NAc shell markedly enhanced cocaine reinforcement of self-administration behavior, as indicated by leftward (long-term) and upward (short-term) shifts in fixed ratio dose-response curves. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 6 | CREB also increased the effort exerted by rats to obtain cocaine on more demanding progressive ratio schedules, an effect highly correlated with viral-induced modulation of BDNF protein in the NAc shell. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 7 | CREB enhanced cocaine reinforcement when expressed either throughout acquisition of self-administration or when expression was limited to postacquisition tests, indicating a direct effect of CREB independent of reinforcement-related learning. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 8 | Downregulating endogenous CREB in NAc shell by expressing a short hairpin RNA reduced cocaine reinforcement in similar tests, while overexpression of a dominant-negative CREB(S133A) mutant had no significant effect on cocaine self-administration. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 9 | Finally, increasing CREB expression after withdrawal from self-administration enhanced cocaine-primed relapse, while reducing CREB levels facilitated extinction of cocaine seeking, but neither altered relapse induced by cocaine cues or footshock stress. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 10 | Together, these findings indicate that CREB activity in NAc shell increases the motivation for cocaine during active self-administration or after withdrawal from cocaine. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 11 | Together, these findings indicate that CREB activity in NAc shell increases the motivation for cocaine during active self-administration or after withdrawal from cocaine. | Cocaine | cAMP responsive element binding protein 1 | Rattus norvegicus |