Title : Development of a double-layer microfluidic chip with flow medium for chemotherapy resistance analysis of lung cancer.

Pub. Date : 2011 Nov

PMID : 22072486






1 Functional Relationships(s)
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1 With this device, human non-small cell lung cancer cell line (SPCA-1) was cultured well; the expression and the activity of multidrug resistance-associated protein (MRP1) were detected by immunofluorescence assay for the cells pretreated with or without MK-571, a known inhibitor of MRP1; apoptosis percentages were assayed for the cells after being treated by the anticancer drug etoposide (VP-16). Etoposide ATP binding cassette subfamily C member 1 Homo sapiens