Title : Inhibitor of κB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

Pub. Date : 2011 Dec 30

PMID : 22065572






3 Functional Relationships(s)
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Protein Name
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1 Here we show that inhibitor of kappaB kinase epsilon (IKKepsilon) phosphorylation of STAT1 at serine 708 (Ser-708) drives IFIT2 expression to mediate anti-WNV effector function of IFN. Serine interferon alpha 1 Homo sapiens
2 Here we show that inhibitor of kappaB kinase epsilon (IKKepsilon) phosphorylation of STAT1 at serine 708 (Ser-708) drives IFIT2 expression to mediate anti-WNV effector function of IFN. Serine interferon alpha 1 Homo sapiens
3 STAT1 Ser-708 phosphorylation occurs independently of IRF-3 but requires signaling through the IFN-alpha/beta receptor as a late event in the IFN-induced innate immune response that coincides with IKKepsilon-responsive ISGs expression. Serine interferon alpha 1 Homo sapiens