Title : Type A monoamine oxidase is associated with induction of neuroprotective Bcl-2 by rasagiline, an inhibitor of type B monoamine oxidase.

Pub. Date : 2012 Apr

PMID : 22065207






2 Functional Relationships(s)
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1 Rasagiline and (-)deprenyl, and also befloxatone, a reversible MAO-A inhibitor, increased Bcl-2 mRNA and protein in SH-SY5Y cells. befloxatone BCL2 apoptosis regulator Homo sapiens
2 MAO-B overexpression inhibited Bcl-2 induction by rasagiline and befloxatone, but did not affect that by (-)deprenyl, suggesting the different mechanisms behind Bcl-2 gene induction by these MAO-B inhibitors. befloxatone BCL2 apoptosis regulator Homo sapiens