Title : Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε.

Pub. Date : 2011

PMID : 22046423






1 Functional Relationships(s)
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1 Co-incubation of myoblasts with CM-PA and the novel and conventional PKC inhibitor Go6983 (but not with the conventional PKC inhibitor Go6976) prevented PKCtheta and epsilon activation, JNK phosphorylation, restored IkappaBalpha mass and reduced proinflammatory cytokine production. 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide mitogen-activated protein kinase 8 Homo sapiens