Title : Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.

Pub. Date : 2011

PMID : 22046282






2 Functional Relationships(s)
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1 Activated gadd153 can generate oxidative damage and reactive oxygen species (ROS), increase beta-amyloid (Abeta) levels, disturb iron homeostasis and induce inflammation as well as cell death, which are all pathological hallmarks of AD. Iron DNA damage inducible transcript 3 Homo sapiens
2 Additionally, 27-OHC-induced tau phosphorylation, ROS generation, TNF-alpha activation, and iron and apoptosis-regulatory protein levels alteration were also markedly reduced by siRNA to gadd153. Iron DNA damage inducible transcript 3 Homo sapiens