Title : High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α.

Pub. Date : 2011

PMID : 22041910






2 Functional Relationships(s)
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1 High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-alpha. pifithrin tumor protein p53 Homo sapiens
2 The induction of IGFBP-3 by PN was inhibited by a p53-specific inhibitor, pifithrin-alpha, in a dose-dependent manner, but was not affected by PD169316 (MAPK inhibitor), AS601245 (c-Jun N-terminal kinase inhibitor) or SL327 (MEK1/2 inhibitor). pifithrin tumor protein p53 Homo sapiens