Title : [The effect of cyclophosphamide on cytokines in patients with primary Sjögren's syndrome-associated interstitial lung disease].

Pub. Date : 2011 Jul

PMID : 22041773






3 Functional Relationships(s)
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1 TNF-alpha level (0.23 +- 0.19) was significantly decreased 3 months after cyclophosphamide treatment (t = 2.533, P < 0.05), and TGF-beta(1) (0.31 +- 0.18) level markedly decreased after 6 months of treatment (t = 2.617, P < 0.05). Cyclophosphamide tumor necrosis factor Homo sapiens
2 TGF-beta(1) (21 +- 14) microg/L level decreased significantly after 3-month treatment, and TNF-alpha level (9.4 +- 1.7) microg/L was decreased after 6 months of cyclophosphamide treatment (t = 2.215, P < 0.05). Cyclophosphamide tumor necrosis factor Homo sapiens
3 CONCLUSION: The mechanisms of cyclophosphamide treatment may be associated with its inhibition on production of TNF-alpha, TGF-beta(1)and MMP-9. Cyclophosphamide tumor necrosis factor Homo sapiens