Pub. Date : 2012 Jan 1
PMID : 22041456
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(- ) and H2O2. | Superoxides | succinate dehydrogenase complex subunit D | Homo sapiens |
| 2 | Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(- ) and H2O2. | Superoxides | succinate dehydrogenase complex subunit D | Homo sapiens |
| 3 | Stable expression of mutant SDHD resulted in 2-fold increases in steady-state levels of superoxide that were accompanied by a significantly increased mutation rate as well as a 70-fold increase in mutation frequency at the hprt locus. | Superoxides | succinate dehydrogenase complex subunit D | Homo sapiens |
| 4 | These results demonstrate that mutations in SDHD cause increased steady-state levels of superoxide which significantly contributed to increases in mutation rates and frequency mediated by superoxide and hydrogen peroxide. | Superoxides | succinate dehydrogenase complex subunit D | Homo sapiens |
| 5 | These results demonstrate that mutations in SDHD cause increased steady-state levels of superoxide which significantly contributed to increases in mutation rates and frequency mediated by superoxide and hydrogen peroxide. | Superoxides | succinate dehydrogenase complex subunit D | Homo sapiens |