Title : Involvement of c-Met- and phosphatidylinositol 3-kinase dependent pathways in arsenite-induced downregulation of catalase in hepatoma cells.

Pub. Date : 2011

PMID : 22040890






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Arsenite decreases catalase activity; it activates phosphatidylinositol 3-kinase (PI3K) and its key downstream effector Akt in a variety of cells. arsenite AKT serine/threonine kinase 1 Homo sapiens
2 Arsenite treatment markedly activated Akt and decreased the levels of both catalase mRNA and protein. arsenite AKT serine/threonine kinase 1 Homo sapiens
3 Both PHA and LY attenuated arsenite-induced activation of Akt. arsenite AKT serine/threonine kinase 1 Homo sapiens