Title : Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.

Pub. Date : 2011 Nov 18

PMID : 22037577






2 Functional Relationships(s)
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1 Chemosensitization to bleomycin by vFLIP accompanied accumulation of gamma-H2AX and G2/M-arrest of cells, while bleomycin-induced DNA damage checkpoints, such as phosphorylation of Chk2 and foci formation of Rad51, were similarly detected in both parental and vFLIP-expressing cells, suggesting that primary DNA damage was not affected by vFLIP. Bleomycin checkpoint kinase 2 Homo sapiens
2 Chemosensitization to bleomycin by vFLIP accompanied accumulation of gamma-H2AX and G2/M-arrest of cells, while bleomycin-induced DNA damage checkpoints, such as phosphorylation of Chk2 and foci formation of Rad51, were similarly detected in both parental and vFLIP-expressing cells, suggesting that primary DNA damage was not affected by vFLIP. Bleomycin checkpoint kinase 2 Homo sapiens