Title : Mammalian target of rapamycin inhibition in macrophages of asymptomatic HIV+ persons reverses the decrease in TLR-4-mediated TNF-α release through prolongation of MAPK pathway activation.

Pub. Date : 2011 Dec 1

PMID : 22025552






1 Functional Relationships(s)
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1 In this study we assessed in these macrophages if the blunted increase in TLR-4-mediated TNF-alpha release induced by lipid A (LA) is associated with PI3K-induced upregulation of mammalian target of rapamycin (mTOR) activity. Lipid A toll like receptor 4 Homo sapiens