Pub. Date : 2012 Jan
PMID : 22024430
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) and 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) enzymes are important in determining the balance of the synthesis of different steroids such as progesterone (P4), glucocorticoids, androgens, and estrogens. | Steroids | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Homo sapiens |
| 2 | The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) and 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) enzymes are important in determining the balance of the synthesis of different steroids such as progesterone (P4), glucocorticoids, androgens, and estrogens. | Steroids | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Homo sapiens |
| 3 | The mathematical model developed in this study simulates the network of reactions catalyzed by 3beta-HSD and P450c17 that characterizes steroid synthesis in human, non-human primate, ovine, and bovine species. | Steroids | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Homo sapiens |
| 4 | The model helps to understand the interplay between fluxes through the Delta(4) and Delta(5) pathways in this network, and how this determines the response of steroid synthesis to the variation in 3beta-HSD activity or in the supply of the precursor substrate, pregnenolone (P5). | Steroids | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | Homo sapiens |