Title : Microbial production of phase I and phase II metabolites of midazolam.

Pub. Date : 2012 Mar

PMID : 22022919






1 Functional Relationships(s)
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1 Midazolam, a potent benzodiazepine derivative and a typical substrate of CYP3A4/3A5, is essentially metabolized in human into 1"-hydroxymidazolam, then eliminated as the corresponding phase II metabolite, the 1"-O-beta-D-glucuronide derivative. 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens