Title : The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes.

Pub. Date : 2012 Jan

PMID : 22017299






3 Functional Relationships(s)
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1 The stimulation of the GSH export from viable astrocytes by indinavir or nelfinavir was completely prevented by the application of MK571, an inhibitor of the multidrug resistance protein 1. Glutathione ATP binding cassette subfamily B member 1 Homo sapiens
2 These data demonstrate that indinavir and nelfinavir stimulate multidrug resistance protein 1-mediated GSH export from viable astrocytes and suggest that treatment of patients with such inhibitors may affect the GSH homeostasis in brain. Glutathione ATP binding cassette subfamily B member 1 Homo sapiens
3 These data demonstrate that indinavir and nelfinavir stimulate multidrug resistance protein 1-mediated GSH export from viable astrocytes and suggest that treatment of patients with such inhibitors may affect the GSH homeostasis in brain. Glutathione ATP binding cassette subfamily B member 1 Homo sapiens