Title : Role of neurosteroids in the anticonvulsant activity of midazolam.

Pub. Date : 2012 Apr

PMID : 22014182






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Besides interacting with the benzodiazepine site associated with GABA(A) receptors, some benzodiazepines act as agonists of translocator protein (18 kDa) (TSPO) to enhance the synthesis of steroids, including neurosteroids with positive modulatory actions on GABA(A) receptors. Benzodiazepines translocator protein Mus musculus
2 Besides interacting with the benzodiazepine site associated with GABA(A) receptors, some benzodiazepines act as agonists of translocator protein (18 kDa) (TSPO) to enhance the synthesis of steroids, including neurosteroids with positive modulatory actions on GABA(A) receptors. Benzodiazepines translocator protein Mus musculus
3 Enhanced neurosteroidogenesis may also be a factor in the actions of other benzodiazepines, even those that only weakly interact with TSPO. Benzodiazepines translocator protein Mus musculus