Title : Relationship of drug metabolizing enzyme genotype to plasma levels as well as myelotoxicity of cyclophosphamide in breast cancer patients.

Pub. Date : 2012 Apr

PMID : 22012257






1 Functional Relationships(s)
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1 PURPOSE: The cytotoxic drug cyclophosphamide (CP) is bioactivated into 4-hydroxy-cyclophosphamide (4-OH-CP) through cytochrome P450 enzymes and cleared through aldehyde dehydrogenase and glutathione S-transferase. Cyclophosphamide glutathione S-transferase kappa 1 Homo sapiens