Title : Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.

Pub. Date : 2012 Dec

PMID : 22006370






1 Functional Relationships(s)
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1 These findings indicate that the COX-2/PGE(2) /EP3 signaling pathway is involved in IGF-1-stimulated mammary tumorigenesis and that COX-2-selective inhibitors may be useful in the prevention or treatment of breast cancer associated with elevated IGF-1 levels in humans. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens