Title : The mechanism of action of the nitrosourea anti-tumor drugs on thioredoxin reductase, glutathione reductase and ribonucleotide reductase.

Pub. Date : 1990 Aug 13

PMID : 2200526






1 Functional Relationships(s)
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1 Since thioredoxin reductase and glutathione reductase function as alternative electron donors in the biosynthesis of deoxyribonucleotides, catalyzed by ribonucleotide reductase, the inhibition of these electron transfer systems by the nitrosoureas could determine the cytostatic property of this homologous series of drugs. Deoxyribonucleotides glutathione-disulfide reductase Homo sapiens