Title : Efficient organocatalytic cross-aldol reaction between aliphatic aldehydes through their functional differentiation.

Pub. Date : 2011 Nov 16

PMID : 21999103






1 Functional Relationships(s)
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1 A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and alpha-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst. Proline synemin Homo sapiens