Pub. Date : 2012 Apr
PMID : 21995500
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | AIMS: The aim of this work was to study if a G1-polyamidoamine dendrimer/siRNA dendriplex can remove the p42 MAPK protein in prostate cancer cells and to potentiate the anti-tumoral effect of the antidiabetic drug metformin and taxane docetaxel. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | RESULTS: The dendriplex siRNA/G1-polyamidoamine dendrimer decreased both p42 MAPK mRNA and protein levels by more than 80%, which potentiates the anti-tumoral effects of metformin. | Metformin | mitogen-activated protein kinase 1 | Homo sapiens |