Title : Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell.

Pub. Date : 2011 Dec

PMID : 21993263






1 Functional Relationships(s)
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1 Selective 5-HT(2A) receptor agonist, DOI, induced JEG-3 cell growth was inhibited by the inhibitor of JAK2 (AG490), MEK1/2 (U0126), phospholipase C-beta (PLC-beta; U73122) and protein kinase C-beta (PKC-beta; Go6976)), whereas the selective phosphatidylinositol 3-kinase (PI3K) inhibitor (LY294002) had no effect. U 0126 5-hydroxytryptamine receptor 2A Homo sapiens