Pub. Date : 2011 Oct
PMID : 21991573
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. | Colforsin | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | After treatment with forskolin for 12 or 24 hours, the number of p-CREB (Ser133) and AQP5 positive cells increased, p-CREB (Ser133) and AQP5 protein increased, and AQP5 mRNA was increased. | Colforsin | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | CONCLUSION: Both H89 (PKA inhibitor) and forskolin (cAMP inducing medicine) regulate AQP5 production through the cAMP-PKA/CREB pathway, which could influence the secretory function of the submucosal glands in nasal epithelium. | Colforsin | cAMP responsive element binding protein 1 | Rattus norvegicus |