Title : Enantioselective capillary electrophoresis for the assessment of CYP3A4-mediated ketamine demethylation and inhibition in vitro.

Pub. Date : 2011 Oct

PMID : 21983822






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1 Enantioselective CE with sulfated cyclodextrins as chiral selectors was used to determine the CYP3A4-catalyzed N-demethylation kinetics of ketamine to norketamine and its inhibition in the presence of ketoconazole in vitro. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens