Title : YHHU0895, a novel synthetic small-molecule microtubule-destabilizing agent, effectively overcomes P-glycoprotein-mediated tumor multidrug resistance.

Pub. Date : 2012 Jan 1

PMID : 21982683






1 Functional Relationships(s)
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1 Notably, P-glycoprotein-overexpressing KBV200 and K562/ADR cells, which are strongly resistant to colchicine, vinorelbine and paclitaxel, were sensitive to YHHU0895 both in vitro and in vivo. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens