Title : Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53.

Pub. Date : 2012 Jan 15

PMID : 21979946






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. NAD tumor protein p53 Homo sapiens
2 This loss of p53 was regulated by MDM2-independent NADH quinone oxidoreductase 1-mediated protein degradation, likely due to the imbalance of flavin adenine dinucleotide/nicotinamide adenine dinucleotide in SDH(var+) cells. NAD tumor protein p53 Homo sapiens