Pub. Date : 2011 Nov
PMID : 21979923
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enzymes involved in duloxetine metabolism are cytochrome P450 isoenzymes (CYP) CYP1A2 and to a lesser extent CYP2D6 whereas the selective serotonin reuptake inhibitor Fluvoxamine is known to be a potent inhibitor of CYP1A2. | Duloxetine Hydrochloride | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | Enzymes involved in duloxetine metabolism are cytochrome P450 isoenzymes (CYP) CYP1A2 and to a lesser extent CYP2D6 whereas the selective serotonin reuptake inhibitor Fluvoxamine is known to be a potent inhibitor of CYP1A2. | Duloxetine Hydrochloride | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | Our findings indicate that duloxetine plasma levels can be enhanced by a potent CYP1A2 inhibition by FLX and that DLX, even in higher plasma levels, seems to be well tolerated. | Duloxetine Hydrochloride | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |