Title : Simvastatin induces the expression of hemeoxygenase-1 against ischemia-reperfusion injury on the testes in rats.

Pub. Date : 2011 Dec 15

PMID : 21968084






3 Functional Relationships(s)
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1 Induction of HO-1 expression by simvastatin was significantly increased at 24 and 48 h. Rats pre-treated with simvastatin showed higher expression of HO-1 protein by Western blotting and immunohistochemistry (IHC), and presented lower caspases-3 activity by caspase-3 activity assay. Simvastatin caspase 3 Rattus norvegicus
2 Induction of HO-1 expression by simvastatin was significantly increased at 24 and 48 h. Rats pre-treated with simvastatin showed higher expression of HO-1 protein by Western blotting and immunohistochemistry (IHC), and presented lower caspases-3 activity by caspase-3 activity assay. Simvastatin caspase 3 Rattus norvegicus
3 Further, lower caspase-3 activities were also noted in simvastatin plus Snpp (SS) group than the control plus Snpp (CS) group. Simvastatin caspase 3 Rattus norvegicus