Title : In the Huh7 Hepatoma Cells Diclofenac and Indomethacin Activate Differently the Unfolded Protein Response and Induce ER Stress Apoptosis.

Pub. Date : 2011

PMID : 21966325






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Diclofenac, as well as indomethacin, is able to activate efficiently only the PERK pathway of the UPR, which induces the expression of the proapoptotic GADD153/CHOP protein. Indomethacin DNA damage inducible transcript 3 Homo sapiens
2 Diclofenac, as well as indomethacin, is able to activate efficiently only the PERK pathway of the UPR, which induces the expression of the proapoptotic GADD153/CHOP protein. Indomethacin DNA damage inducible transcript 3 Homo sapiens