Pub. Date : 2011 Sep 30
PMID : 21962237
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. | Alcohols | interferon alpha 1 | Homo sapiens |
| 2 | Here we hypothesized that alcohol exposure modulates TLR8- and TLR4-ligand-induced monocyte activation and affects both type I IFN and inflammatory cytokine induction. | Alcohols | interferon alpha 1 | Homo sapiens |
| 3 | We found that both acute and prolonged alcohol treatment resulted in inhibition of type I IFN induction by either TLR8 or TLR4 ligands in human monocytes at the protein and mRNA levels. | Alcohols | interferon alpha 1 | Homo sapiens |
| 4 | CONCLUSIONS: These novel results suggest first, that alcohol has a profound inhibitory effect on Type I IFN induction regardless of intracellular (TLR8) or cell surface-derived (TLR4) danger signals. | Alcohols | interferon alpha 1 | Homo sapiens |
| 5 | Second, both acute and prolonged alcohol exposure can inhibit antiviral Type I IFN pathway activation. | Alcohols | interferon alpha 1 | Homo sapiens |