Pub. Date : 2012 Jan
PMID : 21947253
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It has been reported that activation of imidazoline I-1 receptor by rilmenidine increases the expression of FXR in human hepatoma cell line, Hep G2 cell, to regulate the target genes relating to lipid metabolism; activation of FXR by rilmenidine exerts an antihyperlipidemic action. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 2 | It has been reported that activation of imidazoline I-1 receptor by rilmenidine increases the expression of FXR in human hepatoma cell line, Hep G2 cell, to regulate the target genes relating to lipid metabolism; activation of FXR by rilmenidine exerts an antihyperlipidemic action. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 3 | It has been reported that activation of imidazoline I-1 receptor by rilmenidine increases the expression of FXR in human hepatoma cell line, Hep G2 cell, to regulate the target genes relating to lipid metabolism; activation of FXR by rilmenidine exerts an antihyperlipidemic action. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 4 | It has been reported that activation of imidazoline I-1 receptor by rilmenidine increases the expression of FXR in human hepatoma cell line, Hep G2 cell, to regulate the target genes relating to lipid metabolism; activation of FXR by rilmenidine exerts an antihyperlipidemic action. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 5 | Otherwise, rilmenidine increased the phosphorylation of p38 to increase the expression of FXR. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 6 | In conclusion, we suggest that rilmenidine activates I-1 receptor to increase intracellular calcium ions that may enhance the phosphorylation of p38 to higher the expression of FXR for improvement of hepatic steatosis in both animals and cells. | Rilmenidine | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |