Pub. Date : 2011 Dec
PMID : 21946898
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | OBJECTIVES: CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics including the HMG-CoA reductase inhibitor simvastatin. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The objective of this study was to investigate whether a new CYP3A4 functional single nucleotide polymorphism (SNP) in intron 6 (CYP3A4*22) modifies the effect of simvastatin on total cholesterol (TOTc) or LDL cholesterol (LDLc) reduction in a population-based cohort study. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The objective of this study was to investigate whether a new CYP3A4 functional single nucleotide polymorphism (SNP) in intron 6 (CYP3A4*22) modifies the effect of simvastatin on total cholesterol (TOTc) or LDL cholesterol (LDLc) reduction in a population-based cohort study. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | METHODS: In a total of 80 incident simvastatin users, the association between the CYP3A4 intron 6 C>T SNP (rs35599367) and reduction in cholesterol levels was analyzed using linear regression analysis and adjusting for potential confounding factors. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | RESULTS: The CYP3A4*22 allele was associated with a trend towards a stronger simvastatin lipid-lowering response, as reflected by the greater reduction in both TOTc and LDLc levels when compared with homozygous wild type. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | CONCLUSION: The CYP3A4*22 intron 6 SNP T-variant allele was associated with reduced CYP3A4 activity, resulting in a better lipid lowering response to simvastatin, when data were adjusted for confounding factors. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | CONCLUSION: The CYP3A4*22 intron 6 SNP T-variant allele was associated with reduced CYP3A4 activity, resulting in a better lipid lowering response to simvastatin, when data were adjusted for confounding factors. | Simvastatin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |