Title : A high response rate to liposomal doxorubicin is seen among women with BRCA mutations treated for recurrent epithelial ovarian cancer.

Pub. Date : 2011 Dec

PMID : 21945552






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1 METHODS: A retrospective cohort study was conducted to compare the response rate, progression-free, and overall survival among women with BRCA-associated or sporadic ovarian cancer who were treated with Doxil. liposomal doxorubicin BRCA1 DNA repair associated Homo sapiens
2 RESULTS: A response to Doxil was seen in 13 of 23 patients with BRCA mutations (56.5%; 3 by RECIST criteria and 10 by CA125 levels) compared with only 8 of 41 women with non-hereditary cancers (19.5%; 2 by RECIST criteria and 6 by CA125 levels; p=0.004). liposomal doxorubicin BRCA1 DNA repair associated Homo sapiens