Pub. Date : 2011 Nov 21
PMID : 21942922
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | The steady accumulation of tissue DNA adducts in the implant groups corroborates the sustained overexpression of CYP1A1 and 1B1, the cytochrome P450s involved in the conversion of BP to its electrophilic metabolites. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 3 | In contrast, the overexpression of CYP1A1 and 1B1 resulting from the bolus dose of BP lasted only for a few days. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 4 | On the basis of our recent study in which we showed the presence of 17beta-estradiol in the lung, the sustained overexpression of CYP1A1 and 1B1 due to continuous exposure to BP may increase the susceptibility to estrogen-mediated carcinogenicity. | Benzo(a)pyrene | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |