Pub. Date : 2011 Apr
PMID : 21941776
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica]. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | OBJECTIVE: To investigate the effects of schisandrin B (Sch-B) on expression of transforming growth factor-beta1 (TGF-beta1) and signal transduction molecule mRNA in rat lungs exposed to SiO2, and explore the intervention mechanism of Sch-B on pulmonary fibrosis induced by SiO2. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | OBJECTIVE: To investigate the effects of schisandrin B (Sch-B) on expression of transforming growth factor-beta1 (TGF-beta1) and signal transduction molecule mRNA in rat lungs exposed to SiO2, and explore the intervention mechanism of Sch-B on pulmonary fibrosis induced by SiO2. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | OBJECTIVE: To investigate the effects of schisandrin B (Sch-B) on expression of transforming growth factor-beta1 (TGF-beta1) and signal transduction molecule mRNA in rat lungs exposed to SiO2, and explore the intervention mechanism of Sch-B on pulmonary fibrosis induced by SiO2. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | OBJECTIVE: To investigate the effects of schisandrin B (Sch-B) on expression of transforming growth factor-beta1 (TGF-beta1) and signal transduction molecule mRNA in rat lungs exposed to SiO2, and explore the intervention mechanism of Sch-B on pulmonary fibrosis induced by SiO2. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 6 | CONCLUSION: Sch-B can reduce the pulmonary fibrosis induced by SiO2 through inhibition of the mRNA express of TGF-beta1 and Smad4 in the lung tissue, modulating the TGF-beta1/Smad4 signal transduction pathway and inhibiting the target gene activation. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |
| 7 | CONCLUSION: Sch-B can reduce the pulmonary fibrosis induced by SiO2 through inhibition of the mRNA express of TGF-beta1 and Smad4 in the lung tissue, modulating the TGF-beta1/Smad4 signal transduction pathway and inhibiting the target gene activation. | schizandrin B | transforming growth factor, beta 1 | Rattus norvegicus |