Title : The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

Pub. Date : 2012 Mar

PMID : 21941369






1 Functional Relationships(s)
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1 Furthermore, transformed AMPK-/- and TSC1-/- MEFs both have higher total protein synthesis rates than wild-type controls, and translation inhibition using cycloheximide partially restores their anoikis resistance, indicating a mechanism whereby mTORC1 inhibition suppresses anoikis. Cycloheximide CREB regulated transcription coactivator 1 Mus musculus