Title : L-Proline/CoCl2-catalyzed highly diastereo- and enantioselective direct aldol reactions.

Pub. Date : 2011 Sep 19

PMID : 21932236






1 Functional Relationships(s)
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1 In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II). Aldehydes mitochondrially encoded cytochrome c oxidase II Homo sapiens