Pub. Date : 2012 Mar
PMID : 21932165
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the bone-derived hormone FGF23, and the kidney-expressed klotho, CYP27B1, and CYP24A1 genes, which together prevent hyperphosphatemia/ectopic calcification and govern the levels of 1,25D to maintain bone mineral integrity while promoting optimal function of other vital tissues. | 1,25-dihydroxyvitamin D | klotho | Homo sapiens |