Title : Effects of combined levosimendan and vasopressin on pulmonary function in porcine septic shock.

Pub. Date : 2012 Jun

PMID : 21932058






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1 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Norepinephrine interleukin 6 Homo sapiens