Pub. Date : 2011
PMID : 21931768
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-beta-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. | Tretinoin | forkhead box P3 | Mus musculus |
| 2 | BACKGROUND: It has been documented all-trans retinoic acid (atRA) promotes the development of TGF-beta-induced CD4(+)Foxp3(+) regulatory T cells (iTreg) that play a vital role in the prevention of autoimmune responses, however, molecular mechanisms involved remain elusive. | Tretinoin | forkhead box P3 | Mus musculus |
| 3 | METHODOLOGY/PRINCIPAL FINDINGS: Addition of atRA to naive CD4(+)CD25(-) cells stimulated with anti-CD3/CD28 antibodies in the presence of TGF-beta not only increased Foxp3(+) iTreg differentiation, but maintained Foxp3 expression through apoptosis inhibition. | Tretinoin | forkhead box P3 | Mus musculus |
| 4 | METHODOLOGY/PRINCIPAL FINDINGS: Addition of atRA to naive CD4(+)CD25(-) cells stimulated with anti-CD3/CD28 antibodies in the presence of TGF-beta not only increased Foxp3(+) iTreg differentiation, but maintained Foxp3 expression through apoptosis inhibition. | Tretinoin | forkhead box P3 | Mus musculus |
| 5 | Conversely, atRA markedly increased ERK1/2 activation, and blockade of ERK1/2 signaling completely abolished the enhanced effects of atRA on Foxp3 expression. | Tretinoin | forkhead box P3 | Mus musculus |