Pub. Date : 2012 Mar
PMID : 21920623
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The high CYP1B1/CYP1A1 and low COMT/CYP1B1 expression ratios detected in ERalpha(+) tumors suggested an accumulation of 4-hydroxyestradiol metabolite under high body estrogen, whereas comparable CYP1A1 and CYP1B1 expression plus estrogen-inducible COMT expression might favor the formation of 2-methoxyestradiol in ERalpha(-) tumors. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | The high CYP1B1/CYP1A1 and low COMT/CYP1B1 expression ratios detected in ERalpha(+) tumors suggested an accumulation of 4-hydroxyestradiol metabolite under high body estrogen, whereas comparable CYP1A1 and CYP1B1 expression plus estrogen-inducible COMT expression might favor the formation of 2-methoxyestradiol in ERalpha(-) tumors. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | The high CYP1B1/CYP1A1 and low COMT/CYP1B1 expression ratios detected in ERalpha(+) tumors suggested an accumulation of 4-hydroxyestradiol metabolite under high body estrogen, whereas comparable CYP1A1 and CYP1B1 expression plus estrogen-inducible COMT expression might favor the formation of 2-methoxyestradiol in ERalpha(-) tumors. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors. | 4-hydroxyestradiol | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |