Title : ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.

Pub. Date : 2012 Mar

PMID : 21920623






1 Functional Relationships(s)
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Protein Name
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1 Benzo[a]pyrene increased expression of CYP1B1 over CYP1A1 and suppressed estrogen-induced COMT up-regulation in ERalpha(-) tumor cells, probably switching estrogen metabolism to 4-hydroxyestradiol formation and removing the inhibition of 2-methoxyestradiol on ERalpha(-) tumors. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens