Title : Costs and consequences of cellular compartmentalization and substrate competition among human enzymes involved in androgen and estrogen synthesis.

Pub. Date : 2012 Jan

PMID : 21918127






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human cytochromes 17alpha-hydroxylase/17,20-lyase (P450c17) and aromatase (P450arom), always coexpressed with their redox partner NADPH-P450 oxidoreductase (CPR) and 3beta-hydroxysteroid dehydrogenase/delta5-4 isomerase (3betaHSD; types 1 or 2), were compartmentally expressed in different cell populations or coexpressed together with pregnenolone (100 nM) as substrate. Pregnenolone cytochrome P450 family 19 subfamily A member 1 Homo sapiens