Title : Endocannabinoids and prostaglandins both contribute to GnRH neuron-GABAergic afferent local feedback circuits.

Pub. Date : 2011 Dec

PMID : 21917995






3 Functional Relationships(s)
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1 Regulation of GnRH neurons by long-loop gonadal steroid feedback through steroid receptor-expressing afferents such as GABAergic neurons is well studied. Steroids gonadotropin releasing hormone 1 Mus musculus
2 We hypothesized the local GnRH-GABA circuit utilizes glia-derived and/or cannabinoid mechanisms and is altered by steroid milieu. Steroids gonadotropin releasing hormone 1 Mus musculus
3 These data suggest GnRH neurons interact with their afferent neurons using multiple mechanisms and that these local circuits can be modified by both sex and steroid feedback. Steroids gonadotropin releasing hormone 1 Mus musculus