Title : Desmin regulates airway smooth muscle hypertrophy through early growth-responsive protein-1 and microRNA-26a.

Pub. Date : 2011 Dec 16

PMID : 21903578






3 Functional Relationships(s)
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1 We identify that Egr1 (early growth responsive protein-1) activates miR-26a promoter via enhanced phosphorylation of Erk1/2 in ASMCs(Des-/-). asmcs mitogen-activated protein kinase 3 Homo sapiens
2 Moreover, induction of ASMCs(Des-/-) hypertrophy by the Erk-1/2/Egr-1/miR-26a/GSK-3beta pathway is consistent in human recombinant ASMCs, which stably suppresses 90% endogenous desmin expression. asmcs mitogen-activated protein kinase 3 Homo sapiens
3 Moreover, induction of ASMCs(Des-/-) hypertrophy by the Erk-1/2/Egr-1/miR-26a/GSK-3beta pathway is consistent in human recombinant ASMCs, which stably suppresses 90% endogenous desmin expression. asmcs mitogen-activated protein kinase 3 Homo sapiens