Title : Alterations in GABAergic biomarkers in the autism brain: research findings and clinical implications.

Pub. Date : 2011 Oct

PMID : 21901839






1 Functional Relationships(s)
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1 The key synthesizing enzymes for GABA, glutamic acid decarboxylase type 65 and 67 (GAD65 and GAD67), are decreased in the cerebellum and closer examination of mRNA levels revealed that it is largely due to decreases in Purkinje cells and a subpopulation of larger dentate neurons as measured by in situ hybridization studies. gamma-Aminobutyric Acid glutamate decarboxylase 1 Homo sapiens